RTF1 (D7V3W) Rabbit mAb #14737
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 100 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
The RNA polymerase-associated protein RTF1 and the tumor suppressor Cdc73 are responsible for recruitment of the PAF complex to active genes within chromatin (8). The RTF1 protein contains a pair of functional domains: the central plus 3 domain has been identified as a region of ssDNA binding (9), and a smaller histone modification domain (HMD) appears to promote methylation of the histone H3 and ubiquitination of histone H2B (8,10).
- Jaehning, J.A. (2010) Biochim Biophys Acta 1799, 379-88.
- Chaudhary, K. et al. (2007) Oncogene 26, 7499-507.
- Pavri, R. et al. (2006) Cell 125, 703-17.
- Rozenblatt-Rosen, O. et al. (2005) Mol Cell Biol 25, 612-20.
- Zhu, B. et al. (2005) Genes Dev 19, 1668-73.
- Rozenblatt-Rosen, O. et al. (2009) Proc Natl Acad Sci U S A 106, 755-60.
- Farber, L.J. et al. (2010) Mol Carcinog 49, 215-23.
- Warner, M.H. et al. (2007) Mol Cell Biol 27, 6103-15.
- de Jong, R.N. et al. (2008) Structure 16, 149-59.
- Piro, A.S. et al. (2012) Proc Natl Acad Sci U S A 109, 10837-42.
Limited Uses
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