SCAI (D9A7Y) Rabbit mAb #12892
- WB
- IP
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Suppressor of cancer cell invasion (SCAI) is a highly conserved transcriptional cofactor that inhibits the activity of myocardin-related transcription factor (MRTF) family members MAL (MRTF-A), myocardin and OTT-MAL (4,5). SCAI controls the expression of integrin β1 and regulates cell migration and invasion in vitro (4). SCAI has also been shown to play a role in transcriptional regulation in neurons by regulating dendritic morphology through inhibition of the megakaryoblastic leukemia (MKL) family of transcription cofactors (6). Research studies have implicated SCAI in the regulation of the epithelial-to-mesenchymal transition (EMT) as well as in renal fibrosis (7).
- Pipes, G.C. et al. (2006) Genes Dev 20, 1545-56.
- Posern, G. and Treisman, R. (2006) Trends Cell Biol 16, 588-96.
- Olson, E.N. and Nordheim, A. (2010) Nat Rev Mol Cell Biol 11, 353-65.
- Brandt, D.T. et al. (2009) Nat Cell Biol 11, 557-68.
- Brandt, D.T. et al. (2009) Cell Cycle 8, 2523-7.
- Ishikawa, M. et al. (2010) J Biol Chem 285, 32734-43.
- Fintha, A. et al. (2013) Am J Pathol 182, 388-400.
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