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Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody #67380

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 50
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Secernin-1 (F6Q7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total secernin-1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro335 of human secernin-1 protein.

    Background

    Secernin-1, encoded by the gene SCRN1, is a 50 kDa cytosolic protein implicated in a variety of biological functions. Originally discovered as a protein that regulates mast cell exocytosis, secernin-1 has been suggested to play roles in axon growth, endoplasmic reticulum (ER) remodeling, and presynaptic vesicle recycling (1-3). In Alzheimer’s disease (AD), secernin-1 was found to be abundant within amyloid plaques of dystrophic neurites and in neurofibrillary tangles (NFTs). Co-immunoprecipitation of secernin-1 and phosphorylated tau from AD patient brain samples further suggests a direct interaction between these proteins (4,5). Secernin-1 levels were also found to be increased in the cerebrospinal fluid (CSF) of AD patients, correlating with total and phospho-tau levels, suggesting its potential as a diagnostic and prognostic biofluid biomarker (6). Beyond AD, SCRN1 has been identified as a tumor-associated gene, with expression levels implicated in the development and progression of various cancers (7-9).

    Alternate Names

    KIAA0193; SCRN1; secernin 1; Secernin-1; SES1

    For Research Use Only. Not for Use in Diagnostic Procedures.
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