Render Target: STATIC
Render Timestamp: 2024-12-02T11:04:17.776Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-04-05 20:52:36.401
Product last modified at: 2024-11-15T19:30:09.306Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

SERPINB3 (OTI3G4) Mouse mAb #90624

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 44.4
    Source/Isotype IgG1
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SERPINB3 (OTI3G4) Mouse mAb recognizes endogenous levels of SERPINB3 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with full-length human recombinant SERPINB3 protein.

    Background

    SERPINB3 (Serpin Family B Member 3) or SCCA1 (Squamous Cell Carcinoma Antigen 1) belongs to the serpin family and inhibits papain-like cysteine proteases (1). SERPINB3 is unique to the other serpins, as it lacks inhibitory activity against serine proteases but has inhibitory activity against papain-like cysteine proteases cathepsins K, L, and S (1,2). It may function as an inhibitor to modulate the host immune response against tumor cells and can act as a UV-induced apoptosis inhibitor by suppressing the activity of c-Jun NH2-terminal kinase 1 (JNK1) (1,3). SERPINB3 is expressed in normal squamous epithelium and in several organs, including epithelium of the tongue, esophagus, uterine cervix and vagina, Hassall’s corpuscles of the thymus, and some areas of the skin (4). SERPINB3 has been found to be overexpressed and implicated in several types of cancer, including hepatocellular carcinoma (HCC), lung, ovarian, and breast cancer (5-8). It is also overexpressed and implicated in hepatoblastoma, autoimmune disorders, lung fibrosis, cholesteatoma, and skin disease (9-13).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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