Render Target: STATIC
Render Timestamp: 2024-12-10T10:44:04.921Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:59:26.587
Product last modified at: 2024-09-30T08:00:42.363Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SF3B4 (E7R4H) Rabbit mAb #68862

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 48
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SF3B4 (E7R4H) Rabbit mAb recognizes endogenous levels of total SF3B4 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro207 of human SF3B4 protein.

    Background

    SF3B4 is part of the SF3b complex, which associates with the U2 snRNP component of the spliceosome and is essential for spliceosome assembly (1-3). SF3B4 can associate with BMPR-1A to inhibit BMP-mediated cell differentiation (4). Haploinsufficiency of SF3B4 has been described in Nager syndrome, a disease of craniofacial malformation condition (5,6). Increased copy number of SF3B4 has been shown to play a role in hepatocellular carcinoma progression (7-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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