Render Target: STATIC
Render Timestamp: 2025-03-19T11:21:09.008Z
Commit: 779953b12a5930618aae6aca7c87fb286faeb1d7
XML generation date: 2025-03-07 13:20:12.251
Product last modified at: 2025-01-01T09:06:24.040Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Siglec-7 (F6K8J) Rabbit mAb #63704

Filter:
  • F

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Flow Cytometry (Fixed/Permeabilized) 1:100 - 1:400
    Flow Cytometry (Live) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Siglec-7 (F6K8J) Rabbit mAb recognizes endogenous levels of total Siglec-7 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human Siglec-7 protein.

    Background

    Sialic acid-binding Ig-like lectin 7 (Siglec-7), also known as AIRM1, is a member of the CD33-related Siglec family, a subset of the immunoglobulin superfamily of cell surface proteins (1-3). Siglec-7 is found in human immune cells, such as natural killer (NK) cells, monocytes, and neutrophils (1,2). Siglec-7 acts as an immune inhibitory receptor via its intracellular tyrosine-based inhibitory motif (ITIM) (1-5). Downregulation of cell surface Siglec-7 is an early marker of NK cell dysfunction, which can be associated with chronic viral infection or impaired anti-tumor activity (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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