Render Target: STATIC
Render Timestamp: 2024-10-04T09:41:50.952Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SLAMF3/CD229 (E5E8A) Rabbit mAb #62759

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 120, 100
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SLAMF3/CD229 (E5E8A) Rabbit mAb recognizes endogenous levels of total SLAMF3/CD229 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the intracellular domain of human SLAMF3/CD229 protein.

    Background

    Signaling lymphocytic activation molecule family 3 (SLAMF3/CD229) is a type-I transmembrane glycoprotein belonging to the SLAM family of immunoreceptors. Research studies have demonstrated that SLAMF3/CD229 is a homophilic, self-ligating receptor and expression is largely restricted to the surface of T cells and B cells (1,2). The extracellular domain of SLAMF3/CD229 contains a duplicated immunoglobulin (Ig)-like variable-type domain and a duplicated Ig-like C2-type domain, while the cytoplasmic domain is subject to alternative splicing and contains multiple potential tyrosine phosphorylation sites capable of recruiting signaling molecules such as EAT-2 and SAP (1,3,4). Research studies have shown that SLAMF3/CD229 is also highly overexpressed by multiple myeloma plasma cells and drives intracellular signaling cascades that promote plasma cell proliferation and survival (5-7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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