SLBP Antibody #12087
- WB
Inquiry Info. # 12087
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Product Specifications
| REACTIVITY | H M R Dg |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Dg-Dog
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
The expression of replication-dependent histone genes peaks during S phase of the cell cycle. Mammalian SLBP is also cell cycle regulated in most somatic cells, but not in mouse oocytes or embryos, indicating a potential role for SLBP in chromatin organization and remodeling (4).
Phosphorylation of SLBP at Thr61 by CDK1 regulates SLBP stability by targeting the protein for degradation upon completion of DNA synthesis (5). SLBP association with histone mRNA maintains its stability, and is regulated by the peptidyl-prolyl isomerase, Pin1, and PP2A phosphatase (6,7).
- Dominski, Z. et al. (2002) Genes Dev 16, 58-71.
- Dominski, Z. et al. (2001) Mol Cell Biol 21, 2008-17.
- Sànchez, R. and Marzluff, W.F. (2002) Mol Cell Biol 22, 7093-104.
- Allard, P. et al. (2002) J Cell Sci 115, 4577-86.
- Koseoglu, M.M. et al. (2008) Mol Cell Biol 28, 4469-79.
- Zhang, M. et al. (2012) Biochemistry 51, 3215-31.
- Krishnan, N. et al. (2012) Mol Cell Biol 32, 4306-22.
Alternate Names
hairpin binding protein, histone; HBP; histone binding protein; Histone RNA hairpin-binding protein; histone stem-loop binding protein; Histone stem-loop-binding protein; SLBP; stem-loop (histone) binding protein; stem-loop binding protein
Limited Uses
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