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  3. Smad2 (34G6) Mouse mAb

Smad2 (34G6) Mouse mAb #3107

Inquiry Info. # 3107

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    Product Specifications

    REACTIVITY
    SENSITIVITY
    MW (kDa) 58
    Source/Isotype Mouse

    Product Information

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Specificity / Sensitivity

    Smad2 (34G6) Mouse mAb detects total levels of endogenous Smad2.

    Source / Purification

    Monoclonal antibody (isotype: IgG1) is produced by immunizing mice with a synthetic peptide corresponding to C-terminal residues of human Smad2. Antibody is supplied in HEPES buffer with 50% glycerol and less than 0.02% sodium azide.

    Background

    Members of the SMAD family of signal transduction molecules are components of a critical intracellular pathway that transmit TGF-β signals from the cell surface into the nucleus. Three distinct classes of SMADs have been defined: the receptor-regulated SMADs (R-SMADs), which include SMAD1, 2, 3, 5, and 9; the common-mediator SMAD (co-SMAD), SMAD4; and the antagonistic or inhibitory SMADs (I-SMADs), SMAD6 and 7 (1-5). Activated type I receptors associate with specific R-SMADs and phosphorylate them on a conserved carboxy-terminal SSXS motif. The phosphorylated R-SMADs dissociate from the receptor and form a heteromeric complex with SMAD4, initiating translocation of the heteromeric SMAD complex to the nucleus. Once in the nucleus, SMADs recruit a variety of DNA binding proteins that function to regulate transcriptional activity (6-8).

    Alternate Names

    hMAD-2; hSMAD2; JV18; JV18-1; MAD homolog 2; Mad protein homolog; Mad-related protein 2; MAD, mothers against decapentaplegic homolog 2; MADH2; MADR2; MGC22139; MGC34440; mother against DPP homolog 2; Mothers against decapentaplegic homolog 2; Mothers against DPP homolog 2; Sma- and Mad-related protein 2; SMAD 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; SMAD2

    Database Links

    UniProt ID: Q15796


    Entrez-Gene Id: 4087


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