SMUG1 (E7P4I) Rabbit mAb #23522
- WB
- IP
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 29 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:100 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Single-strand-selective monofunctional uracil-DNA glycosylase 1 (SMUG1) removes uracil and oxidized pyrimidines from DNA. SMUG1 expression is important for genome stability, and high expression of SMUG1 is correlated with favorable prognosis in human cancer (3). Knockdown or knockout of SMUG1 results in decreased proliferation, as well as increased DNA damage and apoptosis (4).
Limited Uses
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