Render Target: STATIC
Render Timestamp: 2025-03-14T11:09:07.963Z
Commit: a619ae74f66dae0f27639e88da12bcf600e46428
XML generation date: 2025-03-07 13:16:41.388
Product last modified at: 2025-03-08T00:45:08.257Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

SNARK/NUAK2 (E4V4Q) Rabbit mAb #15452

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 78
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    SNARK/NUAK2 (E4V4Q) Rabbit mAb recognizes endogenous levels of total SNARK/NUAK2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human SNARK/NUAK2 protein.

    Background

    SNARK was identified as an SNF1/AMPK-related kinase and member of the AMPK catalytic subunit family (1,2). This enzyme was separately identified as a TNFα-induced SNF1-like kinase 2 (NUAK2) (3). The kinase activity of SNARK/NUAK2 is increased by AMP and AICAR (1). SNARK/NUAK2 activity is regulated by a variety of cellular stresses such as endoplasmic reticulum (ER) stress and oxidative stresses (4), suggesting that SNARK/NUAK2 is a signaling molecule involved in the cell stress response (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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