SRSF7 (F9G2P) Rabbit mAb #82637
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Serine/arginine-rich splicing factor 7 (SRSF7/SFRS7), also known as splicing factor 9G8, is overexpressed in colon and lung cancer, and regulates proliferation and apoptosis through the splicing of Fas mRNA in human colon and lung cancer cells (2). In human colon cancer cells, SRSF7 knockdown increased levels of the CDK inhibitor p21 Waf1/Cip1 in a p53-independent manner (3). SRSF7 also regulates age-dependent splicing in mice (4) and induces expression of cellular senescence markers in response to DNA damage by generating an alternatively spliced form of p53, p53β (5).
Limited Uses
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