Stargazin Antibody #2503
- WB
Inquiry Info. # 2503
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Product Specifications
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 40 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Interactions between stargazin and AMPA receptors are implicated in regulation of receptor surface expression, synaptic clustering and recycling, as well as increased receptor responsiveness to glutamate (1,2,5,6). Stargazin may play a role in the molecular mechanism of AMPAR-mediated inflammatory pain by taking part in signaling pathways that relay pain in the spinal cord (5). Because the protein also modulates the pharmacology of AMPA receptors, it enhances the effects of AMPAR potentiators that have therapeutic potential for a number of mental and neurodegenerative diseases (6).
The carboxy terminus of the stargazin protein interacts with the PDZ domains of PSD95 and other membrane-associated guanylate kinase (MAGUK) family members, and together traffic AMPA receptors to the cell surface membrane, anchoring them to the postsynaptic site (1,7). Phosphorylation of stargazin by PKA on Thr321 inhibits this binding (3).
- Tomita, S. et al. (2005) Nature 435, 1052-1058.
- Priel, A. et al. (2005) J. Neurosci. 25, 2682-2686.
- Choi, J. et al. (2002) J. Biol. Chem. 277, 12359-12363.
- Osten, P. and Stern-Bach, Y. (2006) Curr. Opin. Neurobiol. 16, 275-280.
- Tao, F. et al. (2006) J. Neurosci. Res. 84, 867-873.
- Tomita, S. et al. (2006) Proc. Natl. Acad. Sci. USA 103, 10064-10067.
- Schnell, E. et al. (2002) Proc. Natl. Acad. Sci. USA 99, 13902-13907.
Alternate Names
CACNG2; calcium channel, voltage-dependent, gamma subunit 2; calcium voltage-gated channel auxiliary subunit gamma 2; CCG2; MGC138502; MGC138504; MRD10; Neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; TARP gamma-2; Transmembrane AMPAR regulatory protein gamma-2; Voltage-dependent calcium channel gamma-2 subunit
Limited Uses
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