Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Syntaxin 1A Antibody recognizes endogenous levels of total syntaxin 1A protein. The antibody may cross-react with syntaxin 1B.
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val237 of human syntaxin 1A protein. Antibodies are purified by protein A and peptide affinity chromatography.
Syntaxin 1A (STX1A) is a SNARE protein involved in intracellular membrane fusion, including synaptic vesicle fusion (1). At the synapse, syntaxin 1 is located at the presynaptic plasma membrane and is therefore categorized as a t-SNARE protein (2). The amino-terminal domain of syntaxin 1 interacts with Munc18-1 and this interaction is essential for synaptic vesicle fusion (3). Although originally characterized from neural tissues, research studies have demonstrated syntaxin 1A expression in exocrine tissues such as pancreatic islets (4) where it negatively regulates insulin release (5).
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