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TAF15 Antibody

TAF15 Antibody #13150

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H M R Mk

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

TAF15 Antibody recognizes endogenous levels of total TAF15 protein.

Species predicted to react based on 100% sequence homology:

Hamster, Bovine, Dog, Pig, Horse

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TAF15 protein. Antibodies are purified by protein A and peptide affinity chromatography.

TBP binding protein associated factor 15 (TAF15) is a member of the multifunctional FET (FUS, EWS, and TAF15) family of proteins that bind both DNA and RNA and may be important for transcriptional regulation and RNA processing (1,2). Research studies show that FET family proteins, including TAF15, can be found as oncogenic fusion proteins with transcription factors in a variety of cancers. The fusion protein consists of the FET protein amino-terminal transcription activation domain and the transcription factor DNA binding domain, creating an aberrant transcription factor with potent transactivation potential (1-3). TAF15 can be part of a subset of the transcription factor IID (TFIID) complex, indicating that it may form a transcription pre-initiation complex at active genes, even if it is not considered a canonical TAF (4,5). Additional studies suggest roles for TAF15 in RNA splicing through its association with U1 small nuclear RNA and in regulation of cell cycle regulatory gene expression through a mechanism involving miRNA biosynthesis (6,7).

  1. Law, W.J. et al. (2006) Brief Funct Genomic Proteomic 5, 8-14.
  2. Kovar, H. (2011) Sarcoma 2011, 837474.
  3. Bertolotti, A. et al. (1999) Oncogene 18, 8000-10.
  4. Bertolotti, A. et al. (1996) EMBO J 15, 5022-31.
  5. Bertolotti, A. et al. (1998) Mol Cell Biol 18, 1489-97.
  6. Jobert, L. et al. (2009) EMBO Rep 10, 494-500.
  7. Ballarino, M. et al. (2013) Oncogene 32, 4646-55.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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