Render Target: STATIC
Render Timestamp: 2024-12-10T11:03:13.569Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:58:36.686
Product last modified at: 2024-09-30T08:00:20.445Z
Cell Signaling Technology Logo
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TASOR (E6M2Y) Rabbit mAb #92278

Filter:
  • WB

    Supporting Data

    REACTIVITY H Mk
    SENSITIVITY Endogenous
    MW (kDa) 195, 210, 250
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TASOR (E6M2Y) Rabbit mAb recognizes endogenous levels of total TASOR protein. This antibody detects 75 and 78 kDa bands of unknown origin.

    Species Reactivity:

    Human, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu844 of human TASOR protein.

    Background

    TASOR (also known as FAM208A or RAP140), along with MPP8, periphilin, and MORC2, comprise members of the human silencing hub (HUSH) complex, which is recruited to sites of H3K9me3 and helps target SETDB1 to maintain transcriptional repression (1,2). In addition to functioning at genomic sites, the HUSH complex also cooperates with TRIM28 to silence LINE-1 elements (3,4). TASOR has been shown to play a critical role in early embryonic development (5,6). Additionally, TASOR cooperates with the RNA deadenylase scaffold protein CNOT1 to repress HIV expression (7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    XP is a registered trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.