PhosphoPlus® TAZ (Ser89) Antibody Duet #80074
Inquiry Info. # 80074
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Product Description
Background
Phosphorylation of TAZ at Ser89 functions to destabilize TAZ protein by promoting 14-3-3 binding, cytoplasmic sequestration, and proteasomal degradation, thereby reducing the ability of TAZ to co-activate transcription of downstream target genes. Mutation of Ser89 to alanine (S89A) yields a constitutively active form of TAZ; expression of TAZ (S89A) in breast cancer cells was shown to promote a cancer stem cell phenotype (5).
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