TFF1/pS2 Antibody #12419
- WB
Inquiry Info. # 12419
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Product Specifications
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 13 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
TFF1 is expressed predominantly by the gastric epithelia, in the upper portion of the glandular pits, and is highly expressed in some adenocarcinomas such as breast cancer (1,3,4). In the context of breast cancer, TFF1 is highly expressed in estrogen receptor-positive tumors. Indeed, TFF1 expression is directly regulated by estrogen receptor-α (4). In the stomach, secreted TFF1 is a component of the protective mucous layer. TFF1 expression is strongly induced after mucosal injury (5) and is involved in stomach ontogenesis and maintenance of the integrity of the mucosa (1,3). Research studies have shown frequent loss of TFF1 expression in more than two-thirds of gastric carcinomas resulting from mutation-independent mechanisms (6-8).
- Madsen, J. et al. (2007) J Histochem Cytochem 55, 505-13.
- Taupin, D. and Podolsky, D.K. (2003) Nat Rev Mol Cell Biol 4, 721-32.
- Ribieras, S. et al. (1998) Biochim Biophys Acta 1378, F61-77.
- Corte, M.D. et al. (2006) Breast Cancer Res Treat 96, 63-72.
- Taupin, D. et al. (2001) Lab Invest 81, 397-408.
- Carvalho, R. et al. (2002) Lab Invest 82, 1319-26.
- Katoh, M. (2003) Int J Mol Med 12, 3-9.
- McChesney, P.A. et al. (2006) Cancer Res 66, 1346-53.
Alternate Names
BCEI; Breast cancer estrogen-inducible protein; breast cancer estrogen-inducible sequence; D21S21; gastrointestinal trefoil protein pS2; HP1.A; HPS2; P04155; pNR-2; Polypeptide P1.A; Protein pS2; pS2; TFF1; Trefoil factor 1
Limited Uses
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