TH1L Antibody #3088
- WB
- IP
Inquiry Info. # 3088
Please see our recommended alternatives.
Product Specifications
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 66 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
In addition to its role in transcription regulation, TH1L is a negative regulator of MAPK signaling by inhibiting A-Raf and PAK1 kinase activities. Research studies have shown that TH1L expression is negatively correlated with breast cancer proliferation and migration (7-9).
- Narita, T. et al. (2003) Mol Cell Biol 23, 1863-73.
- Nechaev, S. and Adelman, K. (2011) Biochim Biophys Acta 1809, 34-45.
- Yamaguchi, Y. et al. (1999) Cell 97, 41-51.
- Buratowski, S. (2009) Mol Cell 36, 541-6.
- Yamaguchi, Y. et al. (2001) Science 293, 124-7.
- Yamaguchi, Y. et al. (2002) Mol Cell Biol 22, 2918-27.
- Cheng, C. et al. (2009) J Biol Chem 284, 8786-96.
- Liu, W. et al. (2004) J Biol Chem 279, 10167-75.
- Zou, W. et al. (2010) Cancer Sci 101, 2156-62.
Alternate Names
HSPC130; Negative elongation factor C/D; negative elongation factor complex member C/D; negative elongation factor proteins C and D; NELF-C; NELF-C/D; NELF-D; NELFCD; NELFD; TH1; TH1 drosophila homolog; TH1-like (Drosophila); TH1-like protein; TH1L; trihydrophobin 1
Limited Uses
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