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  3. Thioredoxin 2 Antibody

Thioredoxin 2 Antibody #13322

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Inquiry Info. # 13322

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    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 13
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Thioredoxin 2 Antibody recognizes endogenous levels of total thioredoxin 2 protein. This antibody may cross-react with unidentified proteins from 60 kDa to 140 kDa.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human thioredoxin 2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond that is then reduced by thioredoxin reductase (1). Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (TRX1) and mitochondrial thioredoxin 2 (TRX2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress, and protein reduction (1). A potential role of thioredoxin in human disorders such as cancer, aging, and heart disease is currently under investigation (2). Thioredoxin can play a key role in cancer progression, because it acts as a negative regulator of the proapoptotic kinase ASK1 (3). Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury (4,5).

    Alternate Names

    COXPD29; mitochondrial thioredoxin; Mt-Trx; MTRX; THIOM; thioredoxin 2; Thioredoxin-2; Thioredoxin, mitochondrial; TRX2; TXN; TXN2

    Database Links

    UniProt ID: Q99757


    Entrez-Gene Id: 25828


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