Render Target: STATIC
Render Timestamp: 2024-10-15T10:07:39.952Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-30 01:54:36.162
Product last modified at: 2024-09-30T08:01:40.496Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TIE1 (D2K2T) Rabbit mAb #23111

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 135, 140
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TIE1 (D2K2T) Rabbit mAb recognizes endogenous levels of total TIE1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human TIE1 protein.

    Background

    TIE1 belongs to the Tie family of receptor tyrosine kinases. TIE1 is structurally similar to its homolog TIE2, but differs from the latter in that it does not have a known ligand and is thus considered an orphan receptor (1). A key function of TIE1 is to modulate TIE2 signaling, via heterodimerization with TIE2 at the cell surface (2). The effects of TIE1-TIE2 interaction are context-dependent; heterodimerization can either promote or inhibit downstream TIE2 signaling depending on localized TIE2 levels (3-6). Research studies have shown TIE1 to be implicated in angiogenesis, vascular maturation, tissue remodeling, and inflammation. Increased expression of TIE1 has also been associated with cancer stemness and atherosclerosis formation (7, 8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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