Render Target: STATIC
Render Timestamp: 2024-10-11T10:04:27.970Z
Commit: 56767fe525c928647c8401233a175d0d607d385d
XML generation date: 2024-09-30 02:00:01.599
Product last modified at: 2024-09-30T08:01:31.727Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TMEM175 (F5G5U) Rabbit mAb #56936

Filter:
  • WB

    Supporting Data

    REACTIVITY M R
    SENSITIVITY Endogenous
    MW (kDa) 60
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TMEM175 (F5G5U) Rabbit mAb recognizes endogenous levels of total TMEM175 protein.

    Species Reactivity:

    Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of mouse TMEM175 protein.

    Background

    Transmembrane protein 175 (TMEM175) is a potassium channel located in the membrane of late endosomes and lysosomes. TMEM175 has been shown to regulate lysosomal membrane potential, pH stability, and organelle fusion. In contrast, TMEM175 deficiency impairs lysosomal pH stability, lysosome-mediated autophagosomal clearance, and mitochondrial clearance in cells (1). Dysfunctional mitophagy resulting from TMEM175 loss-of-function mutations has been implicated in several human central nervous system (CNS) diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) (2-4). Recently, it has been discovered that TMEM175 plays a role in apoptosis, as it is directly inhibited through binding of the anti-apoptotic regulator Bcl-2 (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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