Tox/Tox2 (E6I3Q) Rabbit mAb (BSA and Azide Free) #62886
- WB
- IHC
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
This product is the carrier free version of product #73758. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.Formulation
For standard formulation of this product see product #73758.
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Tox plays a key role in T cell development in the thymus during positive selection (3-5). A study in Tox-deficient mice also revealed a requirement for Tox in CD4 T cell and NK cell lineage development, including NKT cells, FoxP3+ T regulatory T cells, and lymphoid tissue-inducer (LTi) cells (6-8). Although Tox expression is primarily restricted to developing immune cells in normal tissues, Tox is induced by high antigen stimulation during chronic viral infection or cancer, regulating T cell persistence and exhaustion (9-12). Tox has also been shown to be aberrantly expressed in cutaneous T cell lymphomas (13-14).
- O'Flaherty, E. and Kaye, J. (2003) BMC Genomics 4, 13.
- Aliahmad, P. et al. (2012) Curr Opin Immunol 24, 173-7.
- Wilkinson, B. et al. (2002) Nat Immunol 3, 272-80.
- Aliahmad, P. et al. (2004) J Exp Med 199, 1089-99.
- Chi, T.H. et al. (2002) Nature 418, 195-9.
- Aliahmad, P. and Kaye, J. (2008) J Exp Med 205, 245-56.
- Aliahmad, P. et al. (2010) Nat Immunol 11, 945-52.
- Yun, S. et al. (2011) Immunol Lett 136, 29-36.
- Page, N. et al. (2018) Immunity 48, 937-950.e8.
- Alfei, F. et al. (2019) Nature 571, 265-9.
- Yao, C. et al. (2019) Nat Immunol 20, 890-901.
- Wang, X. et al. (2019) J Hepatol pii: S0168-8278(19)30301-0. doi: 10.1016/j.jhep.2019.05.015.
- Morimura, S. et al. (2014) Arch Dermatol Res 306, 843-9.
- Huang, Y. et al. (2014) Oncotarget 5, 4418-25.
Limited Uses
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