TRAF1 Antibody #4714
Inquiry Info. # 4714
Please see our recommended alternatives.
Product Specifications
| REACTIVITY | |
| SENSITIVITY | |
| MW (kDa) | 51 |
| SOURCE | Rabbit |
Product Information
Storage
Specificity / Sensitivity
Source / Purification
Background
TRAF1 is unique amongst the TRAF family in that it does not contain an amino-terminal RING finger (4). TRAF1 has a limited tissue distribution and may be induced by NF-kappaB and inactivated by lymphocytes (4-6). TRAF1 works in conjunction with TRAF2 to suppress caspase activation and TNF-induced apoptosis. It has been shown to associate with a number of cytoplasmic proteins, including TANK/I-TRAF, TRIP, A20, RIP, RIP2, FLIP and c-IAP1/2. During apoptosis, TRAF1 may be cleaved by caspases at Asp163 which can act to inhibit NF-kappaB activation (7,8).
- Arch, R.H. et al. (1998) Genes Dev 12, 2821-30.
- Chung, J.Y. et al. (2002) J Cell Sci 115, 679-88.
- Bradley, J.R. and Pober, J.S. (2001) Oncogene 20, 6482-91.
- Rothe, M. et al. (1994) Cell 78, 681-92.
- Speiser, D.E. et al. (1997) J Exp Med 185, 1777-83.
- Wang, C.Y. et al. (1998) Science 281, 1680-3.
- Henkler, F. et al. (2003) J Biol Chem 278, 29216-30.
- Leo, E. et al. (2001) J Biol Chem 276, 8087-93.
Alternate Names
EBI6; Epstein-Bar virus-induced protein 6; Epstein-Barr virus-induced protein 6; MGC:10353; TNF receptor associated factor 1; TNF receptor-associated factor 1; TRAF1
Limited Uses
Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.
Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.