TRAT1 (E3L8A) Rabbit mAb #51468

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	28, 60
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

TRAT1 (E3L8A) Rabbit mAb recognizes endogenous levels of total TRAT1 protein. This antibody detects TRAT1 monomers and homodimers.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human TRAT1 protein.

Background

T cell receptor-associated transmembrane adaptor 1 (TRAT1) is a transmembrane adaptor protein, which is expressed as a disulfide-linked homodimer on the surface of cells belonging to the T and NK lineage. Research studies have demonstrated that TRAT1 is associated with the T cell receptor (TCR) signaling complex. Furthermore, T cell activation promotes tyrosine phosphorylation of the TRAT1 cytoplasmic tail, which facilitates the recruitment of SH2 domain-containing signaling proteins known to regulate T cell function (1). TRAT1 may also modulate TCR signaling by stabilizing the surface expression of the TCR signaling complex (2).

Database Links

UniProt ID: Q6PIZ9

Entrez-Gene Id: 50852

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For Research Use Only. Not For Use In Diagnostic Procedures.

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