Render Target: STATIC
Render Timestamp: 2024-12-13T11:26:39.088Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:56:08.123
Product last modified at: 2024-09-30T08:01:46.635Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TRBP2 (D7C8K) Rabbit mAb #62043

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 44
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TRBP2 (D7C8K) recognizes endogenous levels of total TRBP2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro119 of human TRBP2 protein.

    Background

    Trans-activation response (TAR) RNA binding protein (TRBP2) was initially discovered as a double stranded RNA binding protein (dsRBP) that bound TAR RNA sequences of the HIV-1 virus (1, 2). TRBP2 can bind to and inhibit the phosphorylation of protein kinase PKR, which leads to increased activation of the HIV-1 long terminal repeat (3,4). Along with PACT, TRBP2 is one of the dsRBPs in the RNA-induced silencing complex (RISC), where it plays a critical role in recruiting Ago2 to the miRNA bound by Dicer. (5-8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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