Render Target: STATIC
Render Timestamp: 2025-02-12T10:53:17.482Z
Commit: 7500bcdc731e9059bbdfbdbe9e72caa896e426e8
XML generation date: 2025-02-04 23:01:16.306
Product last modified at: 2025-02-05T09:00:12.034Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

TRPS1 (ZR382) Rabbit mAb #68310

Filter:
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:50

    Storage

    Supplied in a buffer with protein carrier and preservative. Stable for 24 months when stored at 4°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TRPS1 (ZR382) Rabbit mAb recognizes endogenous levels of total TRPS1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of human TRPS1 protein.

    Background

    TRPS1 is a transcription factor that was initially discovered as being mutated in Tricho-rhino-phalangeal syndrome, a craniofacial and skeletal malformation syndrome (1,2). It was also found to be expressed at higher levels in androgen-dependent prostate cancers, reducing the expression of PSA (3,4). TRPS1 recognizes GATA sequences and represses the activation potential of other GATA factors (5). By repressing STAT3 expression, TRPS1 regulates chondrocyte proliferation and survival (6,7). TRPS1 also can increase the activity of HDAC1 and HDAC4 during mitosis to promote histone deacetylation (8). In addition, TRPS1 binds to the NuRD complex via CHD4 and can repress other key transcription factors such as p63 and estrogen receptor (9-11).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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