Render Target: STATIC
Render Timestamp: 2024-10-09T09:39:35.382Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TUFT1 (E9M2U) Rabbit mAb #86460

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 48
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TUFT1 (E9M2U) Rabbit mAb recognizes endogenous levels of total TUFT1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of murine TUFT1 protein.

    Background

    TUFT1 (Tuftelin 1) is a secreted protein that is primarily expressed in the dental pulp and ameloblasts, the cells responsible for producing and secreting enamel matrix proteins during tooth development. The protein is involved in the formation of enamel crystals and plays a critical role both in tooth development and maintenance (1). Some studies have suggested that TUFT1 may play a potential role in disease. TUFT1 was shown to promote metastasis in pancreatic cancer by promoting EMT (2,3), and unregulated TUFT1 expression was shown to be associated with metastatic potential and a poor prognosis in breast cancer (4). TUFT1 has also been reported to play pro-tumorigenic roles in cancer types such as renal and gastric cancer (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.