Immunohistochemical analysis of human colon tissue using Tyrosinase (T311) Mouse mAb (IHC Specific). Note the lack of staining in the tyrosinase negative tissue.Learn more about how we get our images
Immunohistochemical analysis of human melanoma tissue using Tyrosinase (T311) Mouse mAb (IHC Specific).Learn more about how we get our images
NOTE: Do not allow slides to dry at any time during this procedure.
posted November 2010
revised June 2016
Protocol Id: 70
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Tyrosinase (T311) Mouse mAb detects endogenous levels of total tyrosinase protein.
Tyrosinase (T311) Mouse mAb is produced by immunizing animals with a purified recombinant tyrosinase.
Tyrosinase, found in the membrane of melanosomes (1), is a key enzyme in the biosynthesis of melanin pigments (1,2). It is a melanocyte differentiation antigen and is expressed in normal melanocytes and malignant melanomas (1,3). Tyrosinase is implicated to be an antigen target for melanoma vaccines (1).
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