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Tyrosinase (T311) Mouse mAb (IHC Specific) #9319

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Inquiry Info. # 9319

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    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 70-80
    Source/Isotype Mouse IgG2a
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Specificity / Sensitivity

    Tyrosinase (T311) Mouse mAb (IHC Specific) detects endogenous levels of total tyrosinase protein.

    Species Reactivity:

    Human

    Source / Purification

    Tyrosinase (T311) Mouse mAb is produced by immunizing animals with a purified recombinant tyrosinase.

    Background

    Tyrosinase, found in the membrane of melanosomes (1), is a key enzyme in the biosynthesis of melanin pigments (1,2). It is a melanocyte differentiation antigen and is expressed in normal melanocytes and malignant melanomas (1,3). Tyrosinase is implicated to be an antigen target for melanoma vaccines (1).

    Alternate Names

    ATN; CMM8; LB24-AB; Monophenol monooxygenase; OCA1; OCA1A; OCAIA; oculocutaneous albinism IA; SHEP3; SK29-AB; Tumor rejection antigen AB; TYR; TYRO; Tyrosinase; tyrosinase (oculocutaneous albinism IA)

    For Research Use Only. Not for Use in Diagnostic Procedures.
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