Render Target: STATIC
Render Timestamp: 2024-12-03T12:18:00.207Z
Commit: cd2fae6ca3f811b1ddb1df24ac291ed56d5d501b
XML generation date: 2024-11-26 23:01:10.021
Product last modified at: 2024-12-02T09:00:10.245Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TYRP1 (F1Z7M) Rabbit mAb #58193

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 75
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:50 - 1:100

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    TYRP1 (F1Z7M) Rabbit mAb recognizes endogenous levels of total TYRP1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly83 of human TYRP1 protein.

    Background

    Tyrosinase-related protein 1 (TYRP1) is a highly glycosylated transmembrane, zinc-binding metalloenzyme that belongs to the tyrosinase family. TYRP1 expression promotes melanogenesis and is highly localized to the melanosomal subcellular compartment of skin and retinal pigment epithelium melanocytes in normal tissues (1-3). Research studies have demonstrated that TYRP1 is highly expressed in human melanomas and has been identified as a candidate target of immunotherapeutic modalities given its tissue-restricted expression pattern (4-6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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