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UBR5 Antibody

UBR5 Antibody #8755

This product is discontinued

We recommend the following alternatives

  • WB
  • IP
H M R Mk

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

UBR5 Antibody recognizes endogenous levels of total UBR5 protein.

Species predicted to react based on 100% sequence homology:

Dog, Pig

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human UBR5 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Human E3 identified by differential display (UBR5/EDD) is a HECT domain-containing ubiquitin E3 ligase of the N-end rule pathway that promotes the ubiquitination and proteasomal degradation of proteins harboring N-degrons (1-3). UBR5 represents an ortholog of HYD, the Drosophila hyperplastic discs tumor suppressor gene product but has been found to be overexpressed in breast and ovarian cancers, suggesting a possible role in promoting tumor development (4,5). Research studies have demonstrated that UBR5 is functional within the nucleus as it participates in DNA damage signaling by controlling the activities of Chk2, TopBP1, and RNF168 (6-9). Recently, UBR5 was shown to play a novel role in immune cell function by regulating RORγt stability and IL-17 production by Th17 cells (10).

  1. Sriram, S.M. et al. (2011) Nat Rev Mol Cell Biol 12, 735-47.
  2. Callaghan, M.J. et al. (1998) Oncogene 17, 3479-91.
  3. Tasaki, T. et al. (2005) Mol Cell Biol 25, 7120-36.
  4. Clancy, J.L. et al. (2003) Oncogene 22, 5070-81.
  5. O'Brien, P.M. et al. (2008) Br J Cancer 98, 1085-93.
  6. Munoz, M.A. et al. (2007) Cell Cycle 6, 3070-7.
  7. Henderson, M.J. et al. (2006) J Biol Chem 281, 39990-40000.
  8. Honda, Y. et al. (2002) J Biol Chem 277, 3599-605.
  9. Gudjonsson, T. et al. (2012) Cell 150, 697-709.
  10. Rutz, S. et al. (2015) Nature 518, 417-21.
Entrez-Gene Id
Swiss-Prot Acc.
For Research Use Only. Not For Use In Diagnostic Procedures.

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