Render Target: STATIC
Render Timestamp: 2024-12-12T11:08:20.161Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-09-30 01:59:37.632
Product last modified at: 2024-11-19T14:45:09.382Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

UNC93B1 (E6C3E) Rabbit mAb #93568

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 70
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    UNC93B1 (E6C3E) Rabbit mAb recognizes endogenous levels of total UNC93B1 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr40 of human UNC93B1 protein.

    Background

    Signaling by Toll-like receptors (TLRs) is essential for innate and adaptive immune responses (1-3). The endoplasmic reticulum (ER) protein, UNC93B1, was initially identified by a genetic screen analyzing defects in TLR signaling (1,2). UNC93B1 is a multipass transmembrane protein required for normal TLR function and facilitates trafficking of TLRs from the ER to endolysosomes (4,5). UNC93B1 is essential for signaling of TLR3, TLR7, and TLR9 in both humans and mice, and physically interacts with these TLRs in the ER via adaptor protein complex 2 (AP-2) and syntenin-1 (4-7). Mice carrying mutations in UNC93B1 are susceptible to viral infection and autoimmune disease, and mutations in several regions of UNC93B1 in humans have been implicated in autoimmune diseases such as systemic lupus erythematosus, highlighting the role of UNC93B1 in innate and autoimmunity (7-9).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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