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VKORC1L1 (F9M8G) Rabbit mAb

VKORC1L1 (F9M8G) Rabbit mAb #29458

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	19
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

VKORC1L1 (F9M8G) Rabbit mAb recognizes endogenous levels of total VKORC1L1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human VKORC1L1 protein.

Background

Vitamin K epoxide reductase complex subunit 1-like protein 1 (VKORC1L1) catalyzes the reduction of vitamin K to vitamin K hydroquinone, a radical-trapping antioxidant. Studies show that VKORC1L1 is a potent ferroptosis suppressor. It protects cells from ferroptosis independent of the GSH/GPX4 pathway by generating vitamin K hydroquinone, counteracting lipid peroxidation. In addition, VKORC1L1 is a direct transcriptional repression target of p53. p53 activation inhibits VKORC1L1 expression, sensitizing cells to ferroptosis for tumor suppression. Furthermore, it was shown that the VKORC1L1 inhibitor warfarin promotes ferroptosis and thus suppresses tumor growth in pancreatic cancer mouse models (1,2).

Database Links

UniProt ID: Q8N0U8

Entrez-Gene Id: 154807

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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