Name: VPS26A (E9S7W) Rabbit mAb
Price: 339.00 USD
Availability: InStock

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WB

Supporting Data

REACTIVITY	H M R Mk
SENSITIVITY	Endogenous
MW (kDa)	38
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

VPS26A (E9S7W) Rabbit mAb recognizes endogenous levels of total VPS26A protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro221 of human VPS26A protein.

Background

Vacuolar protein sorting-associated protein 26A (VPS26A), together with VPS29 and VPS35, is part of a trimeric protein complex known as the cargo-selective complex (CSC) (1). The CSC is regarded as the core functional component of the retromer, a multimeric protein complex involved in selective transport of cargo proteins from endosomes to the trans-Golgi network or plasma membrane (2). As part of the CSC, VPS26A does not have intrinsic membrane-binding activity but relies on association with RAB7A for recruitment to the cytosolic face of the endosomal membrane (3,4). Retromer defects are associated with neurological disease, and VPS26A mutations have been linked to perturbed endosomal cargo sorting in atypical parkinsonism (5).

Database Links

UniProt ID: O75436

Entrez-Gene Id: 9559

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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VPS26A (E9S7W) Rabbit mAb #99384