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WFDC2 (E8S8Z) Rabbit Monoclonal Antibody #95822

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 20
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    WFDC2 (E8S8Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total WFDC2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to full-length human WFDC2 protein. This antibody recognizes residues surrounding Pro88 of human WFDC2 protein.

    Background

    WFDC2 (WAP four-disulfide core domain protein 2), also known as human epididymal secretory protein E4 (HE4), is a small secreted broad-range protease inhibitor. WFDC2 is a diagnostic marker in ovarian, endometrial and other cancers, and can be detected in patient serum (1,2). WFDC2 expression promotes tumor growth (3), contributes to metastasis and epithelial mesenchymal transition (EMT) (4), and regulates angiogenesis and immunogenic signaling in the tumor microenvironment (5).

    Alternate Names

    dJ461P17.6; EDDM4; epididymal protein 4; epididymal secretory protein E4; epididymis secretory sperm binding protein; epididymis-specific, whey-acidic protein type, four-disulfide core; HE4; major epididymis-specific protein E4; MGC57529; OTTHUMP00000031141; Putative protease inhibitor WAP5; Q14508; WAP domain containing protein HE4-V4; WAP four-disulfide core domain 2; WAP four-disulfide core domain protein 2; WAP5; WFDC2

    For Research Use Only. Not for Use in Diagnostic Procedures.
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