Render Target: STATIC
Render Timestamp: 2024-10-09T09:40:13.375Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

XRCC2 (E7M8Y) Rabbit mAb #86714

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 29
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    XRCC2 (E7M8Y) Rabbit mAb recognizes endogenous levels of total XRCC2 protein. By western blot, this antibody detects a 40 kDa band of unknown origin.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys267 of human XRCC2 protein.

    Background

    XRCC2 (X-ray repair cross-complementing protein 2) is one of five RAD51 paralogs that form two distinct complexes, BCDX2 (RAD51B, RAD51C, RAD51D, and XRCC2) and CX3 (RAD51C and XRCC3) (1). Along with RAD51, these complexes are crucial in the repair of DNA double-strand breaks through homologous recombination (2) and in response to DNA replication stress (3,4). XRCC2 expression and genetic polymorphisms are associated with the risk and prognosis of human cancer (5-10). In non-small cell lung cancer (NSCLC) XRCC2 reduces sensitivity to chemotherapy and radiation treatment (11).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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