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Render Timestamp: 2024-10-09T09:41:42.160Z
Commit: f04ddd7fea9fb3592f59f61482fcb94610d25cbe
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. ZSCAN4 (E9Z7B) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

ZSCAN4 (E9Z7B) Rabbit mAb #89585

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 60
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Transfected Only

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro240 of human ZSCAN4 protein.

    Background

    Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) is a transcription factor that is selectively expressed in a unique subpopulation of embryonic stem (ES) cells. Embryonic development is initially controlled by maternally-deposited transcripts and subsequently by zygotic transcription, following the maternal-to-zygotic transition and zygotic genome activation (ZGA) (1). ZGA occurs at the 2-cell (2C) stage of embryonic development, and ZSCAN4 is a specific marker of this stage for embryo and ES cells (2). ZSCAN4 has been shown to regulate telomere maintenance in mouse ES cells and bind to nucleosomal microsatellite DNA repeats, which are prone to genomic instability in mouse 2C-like cells (3,4). ZSCAN4 expression has also been positively correlated with derepression of heterochromatin in mouse ES cells (5). Additionally, ZSCAN4 was shown to facilitate alterations to the chromatin landscape and promote the cancer stem cell phenotype in head and neck squamous cell carcinoma (6).

    Database Links

    UniProt ID: Q8NAM6


    Entrez-Gene Id: 201516


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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