SignalScan™ Peptide Mix (SARS-CoV-2) #23733
Inquiry Info. # 23733
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Background
The cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is similar to other coronaviruses, and is comprised of four key structural proteins: S, the spike protein, E, the envelope protein, M, the membrane protein, and N, the nucleocapsid protein (2). Coronavirus spike proteins are class I fusion proteins and harbor an ectodomain, a transmembrane domain, and an intracellular tail (3,4). The highly glycosylated ectodomain projects from the viral envelope surface and facilitates attachment and fusion with the host cell plasma membrane. The ectodomain can be further subdivided into host receptor-binding domain (RBD) (S1) and membrane-fusion (S2) subunits, which are produced upon proteolysis by host proteases at S1/S2 and S2’ sites. S1 and S2 subunits remain associated after cleavage and assemble into crown-like homotrimers (2,4). In humans, both SARS-CoV and SARS-CoV-2 spike proteins utilize the angiotensin-converting enzyme 2 (ACE2) protein as a receptor for cellular entry (5-7). The cell’s subsequent host response to SARS-CoV-2 infection involves complex signaling cascades, observable through perturbations in protein phosphorylation patterns (8,9) that lead to interferon and cytokine production (10).
- Zhou, P. et al. (2020) Nature 579, 270-273.
- Tortorici, M.A. and Veesler, D. (2019) Adv Virus Res 105, 93-116.
- Li, F. et al. (2006) J Virol 80, 6794-800.
- Li, F. (2016) Annu Rev Virol 3, 237-261.
- Shang, J. et al. (2020) Nature 581, 221-224.
- Wrapp, D. et al. (2020) Science 367, 1260-1263.
- Yan, R. et al. (2020) Science 367, 1444-1448.
- Davidson, A.D. et al. (2020) Genome Med 12, 68.
- Bouhaddou, M. et al. (2020) Cell 182, 685-712.e19.
- Blanco-Melo, D. et al. (2020) Cell 181, 1036-1045.e9.
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