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CUT&Tag Resource Center





CUT&Tag: An Introduction

Cleavage Under Targets & Tagmentation (CUT&Tag), like CUT&RUN, is a new chromatin profiling method that requires less of your sample and time. It uses a primary antibody, a secondary antibody, and pAG-Tn5 to identify protein-DNA interactions across the genome for analysis with next-generation sequencing (NGS). A major advantage of CUT&Tag is that the Tn5 also completes the adaptor ligation as part of the assay, which streamlines the DNA library prep.

We have compiled a collection of videos, application notes, eBooks, blogs, and more to help you start using CUT&Tag to profile histones, transcription factors, and cofactors. Go from cells to DNA library with as little as 100,000 cells in just 1-2 days.

CUT&Tag provided under license from Active Motif, Inc. under U.S. Patent No. 10,689,643 and 9,938,524, foreign equivalents, and child patents deriving therefrom. For purchaser’s internal research use only. May not be used for resale, services, or other commercial use.

U.S. Patent No. 11,733,248, foreign equivalents, and child patents deriving therefrom.