Does your CD44 (156-3C11) Mouse mAb #3570 recognize all variants of human CD44?

The CD44 gene encodes 20 exons. Alternative splicing gives rise to CD44s and multiple CD44 variants (CD44v). CD44s is encoded by constant exons 1-5, 16-18, and 20. The CD44 variants are produced by the insertion of variant exons 6–15, typically identified as v1–v10. The CD44 variants can contain one or more variant regions, such as CD44v3, CD44v6, CD44v4–10, or CD44v8–10.  Exon 19 is spliced out in all forms of CD44. 

Our CD44 (156-3C11) Mouse mAb #3570 recognizes residues surrounding Pro210 of human CD44 (UniProt ID #P16070; https://www.uniprot.org/uniprot/P16070), which are encoded by exon 5. Therefore, #3570 is predicted to recognize all variants of human CD44.

 

Last updated: February 27, 2024