Why don't the phosphorylation sites given in the names of your phospho-EGFR antibodies match the same residue numbers in the UniProt sequence (P00533)?

When EGFR was first reported, the phosphorylation sites and corresponding amino acid numbering did not account for a cleaved signal peptide measuring 24 amino acids in length. Considering many EGFR phospho-sites were reported prior to the discovery of the signal peptide, the amino acid position numbering first reported is slightly shifted from the actual position. These phospho-sites are still referred to by their initially reported amino acid position to maintain consistency in the field and thus our product names maintain this nomenclature as well.

Last updated: September 12, 2024