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CBARA1/MICU1 (D4P8Q) Rabbit Monoclonal Antibody #12524

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  • WB

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 47
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CBARA1/MICU1 (D4P8Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total CBARA1/MICU1 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys110 of human CBARA1/MICU1 protein.

    Background

    CBARA1/MICU1 is a mitochondrial protein associated to the mitochondrial inner membrane that is comprised of two EF hand helix-loop-helix motifs. CBARA1/MICU1 is involved in mitochondrial calcium entry, metabolic coupling between cytosolic calcium transients, and activation of matrix dehydrogenases (1). Mitochondrial CBARA1/MICU1 is required to preserve normal mitochondrial calcium concentration below the equilibrium level by interacting with the uniporter pore-forming subunit MCU (2). CBARA1/MICU1 is important in pancreatic β-cell mitochondrial calcium uptake and sustained insulin secretion (3).

    Alternate Names

    ara CALC; atopy related autoantigen; Atopy-related autoantigen CALC; CALC; calcium binding atopy-related autoantigen 1; Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1; CBAA1; CBARA1; DKFZp564C246; EFHA3; FLJ12684; MICU1; mitochondrial calcium uptake 1; MPXPS

    For Research Use Only. Not for Use in Diagnostic Procedures.
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