Product Pathways - Transcription Factors
Lmx1B (D1E2) Rabbit mAb #13457
|13457S||100 µl (10 western blots)||---||In Stock||---|
|13457||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human||Transfected Only||50||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Species predicted to react based on 100% sequence homology: Mouse, Rat.
Specificity / Sensitivity
Lmx1B (D1E2) Rabbit mAb recognizes transfected levels of total Lmx1B protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Lmx1B protein.
LIM homeobox transcription factor 1 β (Lmx1B) is a member of an evolutionarily conserved family of transcription factors that regulate developmental pattern formation in both vertebrates and invertebrates (1). Numerous developmental studies show that Lmx1B is required for vertebrate dorsoventral limb patterning, as well as normal glomerular basement membrane development and typical differentiation of central serotonergic neurons (2,3).
Mutations in the corresponding Lmx1B gene have been associated with nail-patella syndrome (NPS), an autosomal dominant disorder characterized by dysplasia of fingernails, skeletal anomalies and, frequently, renal disease (2). Abnormal developmental disorders such as developmental glaucoma and idiopathic Parkinson’s disease have also been associated with Lmx1B function (4,5).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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