Product Pathways - Adhesion
PVR/CD155 (D3G7H) Rabbit mAb #13544
|13544S||100 µl (10 western blots)||---||In Stock||---|
|13544||carrier free and custom formulation / quantity||email request|
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|W||1:1000||Human, Monkey||Endogenous||80-90 glycosylated 45-50 nonglycosylated||Rabbit IgG|
Species cross-reactivity is determined by western blot.
Applications Key: W=Western Blotting
Specificity / Sensitivity
PVR/CD155 (D3G7H) Rabbit mAb recognizes endogenous levels of total PVR (CD155) protein. Based on the protein sequence, this antibody is expected to recognize the α, β, γ, and δ isoforms of PVR (CD155) protein.
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg172 of human PVR (CD155) protein.
Western blot analysis of extracts from various cell lines using PVR/CD155 (D3G7H) Rabbit mAb (upper) or α-Actinin (D6F6) XP® Rabbit mAb #6487 (lower).
Poliovirus receptor (PVR, CD155) is an immunoglobulin-like, transmembrane glycoprotein originally described as a mediator of poliovirus attachment to cells and later identified as important in adherens junction formation. Also known as nectin-like 5 (Necl-5), PVR binds nectin-3 and interacts with integrin αvβ3 and PDGFR to regulate integrin clustering and focal contact formation at the leading edge of migrating cells (1,2). Research studies demonstrate that PVR and nectin-3 regulate contact inhibition during cell motility and proliferation in transformed 3T3 cells (3). Additional research indicates that PVR (CD155, Necl-5) expression may play a role in invasiveness of lung adenocarcinoma (4,5). In the immune system, CD155 plays a role in natural killer (NK) cell-mediated cytotoxicity (6).
- Takai, Y. et al. (2008) Nat Rev Mol Cell Biol 9, 603-15.
- Sakisaka, T. et al. (2007) Curr Opin Cell Biol 19, 593-602.
- Minami, Y. et al. (2007) Biochem Biophys Res Commun 352, 856-60.
- Tane, S. et al. (2013) Exp Mol Pathol 94, 330-5.
- Nakai, R. et al. (2010) Cancer Sci 101, 1326-30.
- Stanietsky, N. and Mandelboim, O. (2010) FEBS Lett 584, 4895-900.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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