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NSDHL (F3P8W) Rabbit Monoclonal Antibody #15356

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 40
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NSDHL (F3P8W) Rabbit Monoclonal Antibody recognizes endogenous levels of total NSDHL protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human NSDHL protein.

    Background

    NAD(P) dependent steroid dehydrogenase-like (NSDHL) is an enzyme involved in the late stages of cholesterol biosynthesis (1). Mutations in the NSDHL gene are associated with the X-linked conditions CHILD (congenital hemidysplasia with ichthyosiform erythroderma and limb defects) and CK syndromes (2,3). Elevated NSDHL expression has been found in several cancer types, including breast, gastric, pancreatic, and multiple myeloma, and can be a potent driver of metastasis and predictor of poor prognosis (4-8).  

    Alternate Names

    epididymis secretory sperm binding protein; H105E3; NAD(P) dependent steroid dehydrogenase-like; NAD(P) dependent steroid dehydrogenase-like protein transcript; NSDHL; Protein H105e3; SDR31E1; short chain dehydrogenase/reductase family 31E, member 1; Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; XAP104

    For Research Use Only. Not for Use in Diagnostic Procedures.
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