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CX3CR1 (E9J4I) Rabbit Monoclonal Antibody #19771

Filter:
  • F

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Flow Cytometry (Live) 1:50 - 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    CX3CR1 (E9J4I) Rabbit Monoclonal Antibody recognizes endogenous levels of total CX3CR1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human CX3CR1 protein.

    Background

    CX3C chemokine receptor 1 (CX3CR1) is a member of the seven-transmembrane G-protein coupled receptor (GPCR) family. It is a receptor for its sole ligand, CX3CL1, also known as fractalkine or neurotactin (1). Immune cells that express CX3CR1 include monocytes, macrophages, microglia, T helper (Th) 1 cells, CD8+ T effector/memory cells, NK cells, γδ T cells, and dendritic cells (DCs) (1,2). CX3CR1 has been implicated in inflammatory diseases, such as nephropathy and macular degeneration, and HIV co-receptors. It is emerging as an important player in the regulation of insulin secretion and beta cell function (3). In the brain, CX3CR1 expression is microglia-specific and regulates microglial recruitment to sites of neuroinflammation (1,2). Disruption of CX3CL1-CX3CR1 signaling promotes neurodegeneration in mouse models of Parkinson’s disease and amyotrophic lateral sclerosis but might be protective in Alzheimer’s disease (AD) (2,4,5).

    Alternate Names

    Beta chemokine receptor-like 1; C-X-X-X-C Chemokine Receptor 1; C-X3-C CKR-1; C-X3-C motif chemokine receptor 1; CCRL1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; CMKBRL1; CMKDR1; CX3C chemokine receptor 1; CX3C1; CX3CR1; Fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; GPR13; GPRV28; V28

    For Research Use Only. Not for Use in Diagnostic Procedures.
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