APOBEC3A/B/G (5210-87-13) Rabbit Monoclonal Antibody (BSA and Azide Free) #20074
- WB
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 35 |
| Source/Isotype | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #81001
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
APOBEC3A expression is upregulated in several human cancers, and is a major source of mutation in breast cancer (6). APOBEC3A contributes to chromosomal instability and disease progression in pancreatic cancer (7), and upregulates PD-L1 expression in cancer cells (8).
APOBEC3G suppresses the replication of HIV-1 in T cells (9,10). The HIV-1 virion infectivity factor (Vif) inhibits APOBEC3G activity and targets it for proteasomal ubiquitination degradation (11).
- Olson, M.E. et al. (2018) Cell Chem Biol 25, 36-49.
- Siriwardena, S.U. et al. (2016) Chem Rev 116, 12688-12710.
- Cescon, D.W. and Haibe-Kains, B. (2016) Genome Biol 17, 202.
- Zou, J. et al. (2017) Cell Biosci 7, 29.
- Schmitt, C. et al. (2018) Oncol Rep 40, 2742-2749.
- Cortez, L.M. et al. (2019) PLoS Genet 15, e1008545.
- Wörmann, S.M. et al. (2021) Nat Cancer 2, 1338-1356.
- Zhao, K. et al. (2021) Mol Cancer Res 19, 1571-1582.
- Sheehy, A.M. et al. (2002) Nature 418, 646-50.
- Harris, R.S. et al. (2003) Cell 113, 803-9.
- Sheehy, A.M. et al. (2003) Nat Med 9, 1404-7.
Alternate Names
A3B; ABC3B; APOBEC1L; APOBEC3B; apolipoprotein B mRNA editing enzyme catalytic subunit 3B; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B; ARCD3; ARP4; bK150C2.2; cytidine deaminase; DJ742C19.2; DNA dC->dU-editing enzyme APOBEC-3B; FLJ21201; phorbolin 2; phorbolin 3; Phorbolin-1-related protein; Phorbolin-2/3; PHRBNL; Probable DNA dC->dU-editing enzyme APOBEC-3B
Limited Uses
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