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Tug Antibody #2049

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  • WB
  • IP

    Product Specifications

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 70-75
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Tug Antibody detects endogenous levels of total Tug protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids around residue Val542 of human Tug. Antibodies are purified by Protein A and peptide affinity chromatography.

    Background

    Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma (1) and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation (2). Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution (3).

    Alternate Names

    Alveolar soft part sarcoma chromosomal region candidate gene 1 protein; alveolar soft part sarcoma chromosome region, candidate 1; Alveolar soft part sarcoma locus; ASPC1; ASPCR1; ASPL; ASPS; ASPSCR1; ASPSCR1 tether for SLC2A4, UBX domain containing; ASPSCR1, UBX domain containing tether for SLC2A4; FLJ45380; RCC17; renal cell carcinoma gene on chromosome 17; renal cell carcinoma, papillary, 17; Renal papillary cell carcinoma protein 17; Tether containing UBX domain for GLUT4; TUG; UBX domain protein 9; UBX domain-containing protein 9; UBXD9; UBXN9

    For Research Use Only. Not for Use in Diagnostic Procedures.
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