Sox17 (D1T8M) Rabbit Monoclonal Antibody (BSA and Azide Free) #20584
- WB
- IF
Product Specifications
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 55 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #81778
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Transcription factor Sox17 is a Sox family protein with an established role in endoderm specification during development (2). In addition, Sox17 plays essential roles in the maintenance of the hematopoietic stem cell pool (3) and for vascular morphogenesis during development (4,5). Sox17 negatively regulates oligodendrocyte precursor differentiation by antagonizing β-catenin signaling (6). Mutation in the corresponding Sox17 gene in humans is associated with a form of vesicoureteral reflux, a disorder characterized by congenital kidney and urinary tract defects (7).
- Kamachi, Y. and Kondoh, H. (2013) Development 140, 4129-44.
- Engert, S. et al. (2013) Development 140, 3128-38.
- Clarke, R.L. et al. (2013) Nat Cell Biol 15, 502-10.
- Lange, A.W. et al. (2014) Dev Biol 387, 109-20.
- Choi, E. et al. (2012) Stem Cells 30, 2297-308.
- Chew, L.J. et al. (2011) J Neurosci 31, 13921-35.
- Gimelli, S. et al. (2010) Hum Mutat 31, 1352-9.
Alternate Names
FLJ22252; SOX17; SRY (sex determining region Y)-box 17; SRY-box 17; SRY-box transcription factor 17; SRY-related HMG-box transcription factor SOX17; Transcription factor SOX-17; VUR3
Limited Uses
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