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  3. Aspartoacylase (F8X9Z) Rabbit Monoclonal Antibody (IHC/IF Formulated)
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Aspartoacylase (F8X9Z) Rabbit Monoclonal Antibody (IHC/IF Formulated) #23511

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  • IHC
  • IF

    Product Specifications

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Rabbit IgG
    Application Key:
    • IHC-Immunohistochemistry 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:100 - 1:400
    Immunofluorescence (Frozen) 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Aspartoacylase (F8X9Z) Rabbit Monoclonal Antibody (IHC/IF Formulated) recognizes endogenous levels of total aspartoacylase protein. Non-specific staining was observed in pancreatic islets by immunohistochemistry.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro102 of human aspartoacylase protein.

    Background

    Aspartoacylase (ASPA), also known as aminoacylase-2 (ACY-2), is found primarily in oligodendrocytes and is the only enzyme in the brain that hydrolyzes N-acetyl-l-aspartate (NAA) (1,2). NAA is synthesized from l-aspartate and acetyl-CoA in the neuronal mitochondria of brain gray matter and is one of the most abundant amino acid derivatives found in the vertebrate brain, second only to glutamate (2). NAA levels in the brain must be tightly regulated, with abnormally low levels detected in multiple sclerosis and Alzheimer’s disease, and abnormally high levels measured in Canavan disease (3-5). Canavan disease is a fatal neurodegenerative disorder and is the only identified genetic disorder caused by a defect in the processing of a metabolite produced exclusively in the brain (5).

    Alternate Names

    ACY-2; ACY2; aminoacylase 2; Aminoacylase-2; ASP; ASPA; Aspartoacylase; aspartoacylase (Canavan disease)

    Database Links

    UniProt ID: P45381


    Entrez-Gene Id: 443


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    For Research Use Only. Not for Use in Diagnostic Procedures.
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